Coeliac disease is a long-term condition which affects approximately one in 100 people in the UK. This article explores which patients may need to be screened for the condition and the symptoms they may present with. Once diagnosed with the condition, patients need to follow a lifelong gluten-free diet to prevent complications. This article looks at the many roles that general practice nurses (GPNs) have in promoting compliance with the treatment of a gluten-free diet, as well as discussing how they can help to manage the risk of complications such as osteoporosis and infectious disease.